�Understanding the form and function of certain proteins in the human physical structure is becoming faster and easier, thanks to the work of researchers at the University of Illinois.
By combining custom-built spectrometers, novel probe designs and faster pulse sequences, a squad led by Illinois chemistry professor Chad Rienstra has developed unique capabilities for probing protein chemistry and structure through the manipulation of solid-state nuclear magnetic resonance spectroscopy.
The researchers' recent results represent significant advancement toward atomic-scale resolution of protein structure by solid-state NMR spectrometry. The technique can be applied to a large range of membrane proteins and fibrils, which, because they ar not water-soluble, are a great deal not amenable to more than conventional solution NMR spectrographic analysis or X-ray crystallography.
"In our experiments, we explore couplings between atoms in proteins," Rienstra aforesaid. "Our goal is to translate genomic information into high-resolution structural information, and thereby be able to better empathise the function of the proteins."
Solid-state NMR spectroscopy relaxes the need for solvability of the sample. In solution NMR spectroscopy, molecules are allowed to tumble randomly in the charismatic field. In solid-state NMR spectroscopy, molecules are immobilized within a small cylinder called a rotor. The rotor is then spun at high speed in the magnetic field.
"With increased speed and sensitivity, we can get very heights resolution spectra," Rienstra said. "And, because we commode resolve thousands of signals at a time - one for each atom in the sample - we can buoy determine the structure of the intact protein."
To amend sensitivity and accelerate information collection, Rienstra's group is developing smaller rotors that can be spun at rates surpassing 25,000 rotations per second. The faster rotation rate and smaller sample size allows the researchers to hold more data in less time, and solve structure with just a few milligrams of protein.
The determination of protein structure benefits not only from improvements in engineering, but too from the researchers' novel approach to refining geometric parameters.
Structure determination is ordinarily based upon distances between atoms. Rienstra discovered a way of measuring both the distance between atoms and their relative orientations with very high precision.
"Using this technique, we pot more exactly define the fragments of the particle, and how they ar oriented," Rienstra said. "That allows us to delineate protein features and ascertain structure at the atomic scale."
Rienstra will describe his group's modish findings and techniques at the home meeting of the American Chemical Society, to be held in Philadelphia, Aug. 17-21. Rienstra and his collaborators described their work - creating the highest resolution protein structure resolved by solid-state NMR - in the March 25 issue of the Proceedings of the National Academy of Sciences.
The work was funded by the National Science Foundation and the National Institutes of Health.
Source: James E. Kloeppel
University of Illinois at Urbana-Champaign
More info
Sunday, 24 August 2008
Thursday, 14 August 2008
Canada's Government Announces Aboriginal Health Care Reform In Nova Scotia
� The Honourable Chuck Strahl, Minister of Indian Affairs and Northern Development and Federal Interlocutor for M�tis and Non-Status Indians, on behalf of the Honourable Tony Clement, Minister of Health, announced today reforms that will serve improve the delivery of Aboriginal health care in Nova Scotia.
The Aboriginal Health Transition Fund proclaimed today is designed to improve the integration of Federal and Provincial health services, improve access to health services and increase the participation of Aboriginal peoples in the figure, delivery and evaluation of health programs and services to take them better suited to Nova Scotia's Aboriginal community. Canada's Government is investing over $3 million towards this Fund.
"Our government activity is pleased to denote these important changes in health upkeep services that will better serve the unique of necessity of Aboriginal people in Nova Scotia," said Minister Strahl. "These reforms will help more Aboriginal people plan, redeem and assess health programs and services with the goal of improving the health and well-being our First Nations' people in Nova Scotia."
"Today's announcement demonstrates the positive and growing running relationship we have been developing in Nova Scotia," said Minister Angus MacIsaac, Nova Scotia's Deputy Premier and Acting Minister of Aboriginal Affairs. "It will help fetch all of us closer to the goal of improving the health of Aboriginal Nova Scotians."
"Our Chiefs panorama this investment as a real opportunity to help improve wellness services for Aboriginal mass in Nova Scotia," said Chief Lawrence Paul, Co-Chair of the Atlantic Policy Congress of First Nations Chiefs. "Our Chiefs are very surefooted that by working together, these projects will plow some of the priorities and issues facing First Nations people and avail meet our objective of improving the overall health of our people and our communities."
The Aboriginal Health Transition Fund was established to devise fresh ways of integrating and adapting health services to better meet the inevitably of Aboriginal people. Canada's Government is investing $200 million over 5 years in all provinces.
Background
The Aboriginal Health Transition Fund provides transitional funding to Provincial and Territorial governments and First Nations, Inuit and M�tis organizations and communities in three areas:
Integration - to support First Nations and Inuit communities in improving the coordination and integration 'tween provincial/territorial health systems and health systems within First Nations and Inuit communities.
Adaptation - to sustenance provincial and territorial governments in adapting their existing health programs to the unique inevitably of all Aboriginal peoples.
Pan-Canadian - to financial backing cross-jurisdictional First Nations, Inuit and M�tis priorities or shared priorities in adaptation and carrying out initiatives.
The following projects will be initiated as a result of the AHTF:
Integration Projects
Nova Scotia Federal First Nations Home Care Service and Policy Integration Initiative -- $180,000. This send off will wagerer integrate domicile and continuing care services for First Nations in Nova Scotia. Partners include the Nova Scotia Department of Health's Continuing Care Branch, the Union of Nova Scotia Indians, the Confederacy of Mainland Mi'kmaq and Health Canada.
Enhancement of Health Authority and First Nations Communication, Service Coordination and Access -- $127,five hundred. A Memorandum of Understanding will be developed between two First Nations communities and the Guysborough Antigonish Strait Health Authority (GASHA) to clarify roles and responsibilities for health service legal transfer, establish specific targets and improve coordination of wellness services. Partners include GASHA, the Paq'tnket First Nation, the Potlotek First Nation and Health Canada.
Collaboration for Improved Integration of Mental Health Services in Pictou Landing First Nation -- $187,500. This jut will facilitate increase the capacity of First Nation community health staff to respond to mental health issues, design and apply on reserve support groups and evolve a strategy for better collaboration between the Pictou Landing First Nation and the Pictou County Health Authority.
Project to Improve Mental Health Services and Address the Complex Discharge Planning Needs of First Nations Residents -- $143,600. The Annapolis Valley District Health Authority (DHA) testament work with three First Nation communities and the South West Nova DHA to improve mental wellness services and discharge preparation for composite cases. Other partners include the Acadia First Nation, the Bear River First Nation and the Annapolis Valley First Nation.
Collaborative Care for the Children and Youth We Share -- $215,075. This project volition work with partners to develop collaborative mechanisms, policies and procedures to ameliorate the delivery of mental health services for children and youth in Aboriginal communities. Partners include the Confederacy of Mainland Mi'kmaq, the Annapolis Valley DHA, the Capital Health IWK Health Centre, Colchester East Hants DHA, Eastern Shore Musquodobit Community Health, GASHA, Pictou County Health Authority, and the South West Nova DHA.
Telling Our Stories: Quantifying, Documenting and Articulating First Nations' Health Needs -- $376,193. This project will address the gaps in the collection and access of Aboriginal health information through the development of health indicators and the sharing of health information. Partners include five Cape Breton First Nations communities, GASHA, the Cape Breton DHA, Cancer Care Nova Scotia, Cardiovascular Health Nova Scotia, the Reproductive Care Program of Nova Scotia, the Population Health Research Unit, the Nova Scotia Department of Health and the We'koqma'q Health Centre.
Working Toward Health Status Reporting with First Nations in Nova Scotia (A Project to Prepare First Nation Communities for Panorama Implementation) -- $245,000. This project will improve the integrating and coordination of provincial, community and federal wellness services for First Nations by working to implement the pan-Canadian Public Health Surveillance Management System (Panorama). Partners include the Wagmatcook First Nation, the Nova Scotia Department of Health Promotion and Protection, the Cape Breton DHA, Health Canada, the Confederacy of Mainland Mi'kmaq, and Cape Breton First Nations.
Adaptation Projects
Mental Health and Addictions Prevention and Promotion Initiative; Colchester - East Hants Health Authority -- $208,000. This project will fund First Nations in Millbrook and Indian Brook to work with Colchester East Hants Health Authority to develop a partnership to address the significant health needs related to to mental health forwarding and addictions prevention. It will adapt tools and processes related to to the delivery of mental wellness and addictions services in order to address the cultural context in which prevention and promotion supports are provided. The Government of Nova Scotia, Department of Health is the pient of this project.
The Path Less Travelled: Using Navigation Approaches to Improve the Capacity of Aboriginal Patients to Access the Health System; Cape Breton Nova Scotia First Nations (Tui'kn communities) -- $275,000. This project will adapt training materials and referral processes for Aboriginal people diagnosed with cancer, adapting the Cancer Care Nova Scotia approach. It will meliorate the feel of Aboriginal patients in the health care system by adapting navigation and co-ordination tools and strengthening local capacity to support patients and their families who are facing chronic diseases and accessing discussion from many different agencies. The Government of Nova Scotia, Department of Health is the recipient of this project.
Aboriginal Health Awareness Project; Native Council of Nova Scotia -- $223,500. This project will assess the health necessarily of off-reserve Aboriginal peoples and part information in order to assist with planning and delivery of services to improve accessibility to off-reserve Aboriginal peoples in Nova Scotia, and will create a database and resource guide of province-wide health programs and services to enable off-reserve Aboriginal people to be aware of these services and enable better access. The Government of Nova Scotia, Department of Health is the recipient of this externalize.
In addition to the adaptation projects listed above, Nova Scotia receives finances to put through its adaptation plan -- $275,000.
Pan-Canadian Projects
Improving Pathways to Mental Health in Nova Scotia and New Brunswick -- $598,881. This protrude is intentional to ameliorate access to mental wellness services in communities affiliated with the Atlantic Policy Congress of First Nation Chiefs; better the mental health cognition of community workers; and increase the efficiency of the mental health organisation through the introduction of "health navigators." Mental wellness service assessments will be conducted in each community of interests to estimate the capacity of the formal mental health system and expose informal pathways to genial health service. Partners let in Colchester East Hants, Pictou County, and River Valley Health Authorities; Millbrook, Indian Brook, Tobique, Woodstock, Kingsclear, St. Mary's, Oromocto, and Pictou Landing First Nations.
Midwifery in Aboriginal Community Settings -- $199,900. This project will help the Atlantic Policy Congress of First Nations Chiefs in conducting a research project on traditional midwifery and develop and recommend an implementation scheme for providing midwifery services in Aboriginal communities, in keeping with provincial programs. Partners include five First Nations: Chapel Island, Eskasoni, Membertou, Wagmatcook, Waycobah; the Nova Scotia Department of Health, Primary Health Care Section; the Cape Breton Regional Hospital; the Inverness Consolidated Memorial Hospital; and the Association of Nova Scotia Midwives.
Health Canada
More info
The Aboriginal Health Transition Fund proclaimed today is designed to improve the integration of Federal and Provincial health services, improve access to health services and increase the participation of Aboriginal peoples in the figure, delivery and evaluation of health programs and services to take them better suited to Nova Scotia's Aboriginal community. Canada's Government is investing over $3 million towards this Fund.
"Our government activity is pleased to denote these important changes in health upkeep services that will better serve the unique of necessity of Aboriginal people in Nova Scotia," said Minister Strahl. "These reforms will help more Aboriginal people plan, redeem and assess health programs and services with the goal of improving the health and well-being our First Nations' people in Nova Scotia."
"Today's announcement demonstrates the positive and growing running relationship we have been developing in Nova Scotia," said Minister Angus MacIsaac, Nova Scotia's Deputy Premier and Acting Minister of Aboriginal Affairs. "It will help fetch all of us closer to the goal of improving the health of Aboriginal Nova Scotians."
"Our Chiefs panorama this investment as a real opportunity to help improve wellness services for Aboriginal mass in Nova Scotia," said Chief Lawrence Paul, Co-Chair of the Atlantic Policy Congress of First Nations Chiefs. "Our Chiefs are very surefooted that by working together, these projects will plow some of the priorities and issues facing First Nations people and avail meet our objective of improving the overall health of our people and our communities."
The Aboriginal Health Transition Fund was established to devise fresh ways of integrating and adapting health services to better meet the inevitably of Aboriginal people. Canada's Government is investing $200 million over 5 years in all provinces.
Background
The Aboriginal Health Transition Fund provides transitional funding to Provincial and Territorial governments and First Nations, Inuit and M�tis organizations and communities in three areas:
Integration - to support First Nations and Inuit communities in improving the coordination and integration 'tween provincial/territorial health systems and health systems within First Nations and Inuit communities.
Adaptation - to sustenance provincial and territorial governments in adapting their existing health programs to the unique inevitably of all Aboriginal peoples.
Pan-Canadian - to financial backing cross-jurisdictional First Nations, Inuit and M�tis priorities or shared priorities in adaptation and carrying out initiatives.
The following projects will be initiated as a result of the AHTF:
Integration Projects
Nova Scotia Federal First Nations Home Care Service and Policy Integration Initiative -- $180,000. This send off will wagerer integrate domicile and continuing care services for First Nations in Nova Scotia. Partners include the Nova Scotia Department of Health's Continuing Care Branch, the Union of Nova Scotia Indians, the Confederacy of Mainland Mi'kmaq and Health Canada.
Enhancement of Health Authority and First Nations Communication, Service Coordination and Access -- $127,five hundred. A Memorandum of Understanding will be developed between two First Nations communities and the Guysborough Antigonish Strait Health Authority (GASHA) to clarify roles and responsibilities for health service legal transfer, establish specific targets and improve coordination of wellness services. Partners include GASHA, the Paq'tnket First Nation, the Potlotek First Nation and Health Canada.
Collaboration for Improved Integration of Mental Health Services in Pictou Landing First Nation -- $187,500. This jut will facilitate increase the capacity of First Nation community health staff to respond to mental health issues, design and apply on reserve support groups and evolve a strategy for better collaboration between the Pictou Landing First Nation and the Pictou County Health Authority.
Project to Improve Mental Health Services and Address the Complex Discharge Planning Needs of First Nations Residents -- $143,600. The Annapolis Valley District Health Authority (DHA) testament work with three First Nation communities and the South West Nova DHA to improve mental wellness services and discharge preparation for composite cases. Other partners include the Acadia First Nation, the Bear River First Nation and the Annapolis Valley First Nation.
Collaborative Care for the Children and Youth We Share -- $215,075. This project volition work with partners to develop collaborative mechanisms, policies and procedures to ameliorate the delivery of mental health services for children and youth in Aboriginal communities. Partners include the Confederacy of Mainland Mi'kmaq, the Annapolis Valley DHA, the Capital Health IWK Health Centre, Colchester East Hants DHA, Eastern Shore Musquodobit Community Health, GASHA, Pictou County Health Authority, and the South West Nova DHA.
Telling Our Stories: Quantifying, Documenting and Articulating First Nations' Health Needs -- $376,193. This project will address the gaps in the collection and access of Aboriginal health information through the development of health indicators and the sharing of health information. Partners include five Cape Breton First Nations communities, GASHA, the Cape Breton DHA, Cancer Care Nova Scotia, Cardiovascular Health Nova Scotia, the Reproductive Care Program of Nova Scotia, the Population Health Research Unit, the Nova Scotia Department of Health and the We'koqma'q Health Centre.
Working Toward Health Status Reporting with First Nations in Nova Scotia (A Project to Prepare First Nation Communities for Panorama Implementation) -- $245,000. This project will improve the integrating and coordination of provincial, community and federal wellness services for First Nations by working to implement the pan-Canadian Public Health Surveillance Management System (Panorama). Partners include the Wagmatcook First Nation, the Nova Scotia Department of Health Promotion and Protection, the Cape Breton DHA, Health Canada, the Confederacy of Mainland Mi'kmaq, and Cape Breton First Nations.
Adaptation Projects
Mental Health and Addictions Prevention and Promotion Initiative; Colchester - East Hants Health Authority -- $208,000. This project will fund First Nations in Millbrook and Indian Brook to work with Colchester East Hants Health Authority to develop a partnership to address the significant health needs related to to mental health forwarding and addictions prevention. It will adapt tools and processes related to to the delivery of mental wellness and addictions services in order to address the cultural context in which prevention and promotion supports are provided. The Government of Nova Scotia, Department of Health is the pient of this project.
The Path Less Travelled: Using Navigation Approaches to Improve the Capacity of Aboriginal Patients to Access the Health System; Cape Breton Nova Scotia First Nations (Tui'kn communities) -- $275,000. This project will adapt training materials and referral processes for Aboriginal people diagnosed with cancer, adapting the Cancer Care Nova Scotia approach. It will meliorate the feel of Aboriginal patients in the health care system by adapting navigation and co-ordination tools and strengthening local capacity to support patients and their families who are facing chronic diseases and accessing discussion from many different agencies. The Government of Nova Scotia, Department of Health is the recipient of this project.
Aboriginal Health Awareness Project; Native Council of Nova Scotia -- $223,500. This project will assess the health necessarily of off-reserve Aboriginal peoples and part information in order to assist with planning and delivery of services to improve accessibility to off-reserve Aboriginal peoples in Nova Scotia, and will create a database and resource guide of province-wide health programs and services to enable off-reserve Aboriginal people to be aware of these services and enable better access. The Government of Nova Scotia, Department of Health is the recipient of this externalize.
In addition to the adaptation projects listed above, Nova Scotia receives finances to put through its adaptation plan -- $275,000.
Pan-Canadian Projects
Improving Pathways to Mental Health in Nova Scotia and New Brunswick -- $598,881. This protrude is intentional to ameliorate access to mental wellness services in communities affiliated with the Atlantic Policy Congress of First Nation Chiefs; better the mental health cognition of community workers; and increase the efficiency of the mental health organisation through the introduction of "health navigators." Mental wellness service assessments will be conducted in each community of interests to estimate the capacity of the formal mental health system and expose informal pathways to genial health service. Partners let in Colchester East Hants, Pictou County, and River Valley Health Authorities; Millbrook, Indian Brook, Tobique, Woodstock, Kingsclear, St. Mary's, Oromocto, and Pictou Landing First Nations.
Midwifery in Aboriginal Community Settings -- $199,900. This project will help the Atlantic Policy Congress of First Nations Chiefs in conducting a research project on traditional midwifery and develop and recommend an implementation scheme for providing midwifery services in Aboriginal communities, in keeping with provincial programs. Partners include five First Nations: Chapel Island, Eskasoni, Membertou, Wagmatcook, Waycobah; the Nova Scotia Department of Health, Primary Health Care Section; the Cape Breton Regional Hospital; the Inverness Consolidated Memorial Hospital; and the Association of Nova Scotia Midwives.
Health Canada
More info
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